Genetic Testing for Products of Conception (Abortion Cases)

Genetic Testing for Products of Conception (POC): A Comprehensive Guide

Products of Conception (POC) refers to fetal tissue collected following a miscarriage or spontaneous pregnancy loss. Genetic testing of POC samples can provide crucial insights into the underlying causes of pregnancy loss, helping guide future pregnancy planning with clarity and compassion.

Why Consider POC Testing?

1. Understanding Cause & Recurrence Risk

• Genetic abnormalities—particularly chromosomal issues—are found in over 55% of recurrent pregnancy loss cases Natera+15RBMO Journal+15Pinterest+15.

• Identifying the genetic cause can offer peace of mind and actionable guidance.

2. Helps Guide Future Planning

• A clear explanation of the cause enables couples to make informed decisions about treatment options, fertility planning, or assisted reproductive technologies.

3. Informed Reproductive Counselling

• Genetic results empower clinicians and families with insights for accurate counseling, risk prediction, and care tailoring.

Key Testing Options for POC Samples

• Karyotyping – Detects large chromosome abnormalities like aneuploidies, triploidy, or large deletions/duplications FertSterT+6Natera+6Parents+6igenomix.eutdlpathology.com+1.

• FISH (Fluorescence In Situ Hybridization) – Targets specific chromosomal regions and works on non-dividing cells, though limited to known targets.

• Chromosomal Microarray (CMA) – High-resolution testing that identifies submicroscopic copy number variants (CNVs) across the genome FertSterT.

What the Infographic Illustrates

• Estimated Pregnancy Loss Rates – A visual breakdown of miscarriage frequencies, with insights into chromosomal causes.

• Reasons for Genetic Referral – From causal investigation to recurrence assessment and future pregnancy support.

• Available Testing Options vs. Indications – A clear framework to choose the right test based on clinical indications and patient history.

Clinical Benefits of POC Testing

• Offers explanations for miscarriages rather than facing uncertainty.

• Helps determine the next steps: whether to observe, pursue genetic counseling, or consider advanced options like IVF with PGT.

• Particularly relevant in cases of recurrent pregnancy loss or after assisted reproduction.

LABASSURE Offers Compassionate, High-Quality POC Genetic Testing

• Comprehensive testing spectrum: Karyotype, FISH, and high-resolution microarray.

• Expert genetic interpretation and personalized counseling support families through recovery and future pregnancies.

• Faster turnaround times and streamlined workflows for sensitive, timely care.

Summary at a Glance

Feature

Benefits

Genetic Clarity

Identifies chromosomal causes in most miscarriages

Informed Planning

Guides clinical decisions and future reproductive strategies

Test Options

Tailored selection—Karyotyping, FISH, CMA depending on case

Support & Counseling

Provides emotional and clinical support throughout testing journey

📧 Need a POC genetic test in India or consultation on recurrent loss? Write to us at info@labassure.com

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